I went for consecration first. This will be the key part of your tanking rotation.
I used 2 handers for questing up until I got the SM quest sword around lvl 36. I've only used 1h since then (I have nothing to back that up as the correct choice!).
As for advice, I'm no expert but what worked for me:
1. Get mining/engineering. You are going to want to pull with grenades.
2. Mix a bit of int into your gear early on until you get seal of wisdom
3. Get a fast 1h. The SM quest sword lasted me a long time.
4. Give people Salv if they can't control agro. They may bitch and moan, but it'll make run faster and they'll probably do more dps.